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Research / UCCRI/ Clinical Trials

Clinical Trials

Below is a list of clinical trials being conducted by the UCCRI at St. Joseph's Healthcare Hamilton. The study name, description, enrolment status is provided, along with the name and extension of the coordinator managing the research. To contact a research coordinator, call 905-522-1155 (St. Joe's main line) followed by the extension.

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The UCCRI is based at St. Joe's, with physicians across the Hamilton area. For a list of genitourinary and renal clinical trials at the Juravinski Cancer Centre, click here

 

Renal Trials

Study Name Description Status Contact
CLEAR A Multicenter, Open-label, Randomized, Phase 3 Trial to Compare the Efficacy and Safety of Lenvatinib in Combination with Everolimus or Pembrolizumab Versus Sunitinib Alone in First-Line Treatment of Subjects with Advanced Renal Cell Carcinoma (CLEAR) Enrolment Closed

Liz

x35214

PAPMET/REC.3 A Randomized, Phase ll Efficacy Assessment of Multiple MET Kinase Inhibitors (Cabozantinib, Crizotinib, Savolitinib, and Sunitinib in Metastatic Papillary Renal Carcinoma Open

Camilla

x35876

PROSPER/REC.4

A Phase 3 RandOmized Study Comparing PERioperative Nivolumab vs. Observation in Patients with Renal Cell Carcinoma Undergoing Nephrectomy (PROSPER RCC)

Not Open Yet

Camilla

x35876

 

Bladder

Study Name Description Status Contact
MERCK KEYNOTE-676 A Phase 3, Randomized, Comparator-controlled Clinical Trial to Study the Efficacy and Safety of Pembrolizumab (MK-3475) in Combination with Bacillus Calmette-Guerin (BCG) in Participants with High-risk Non-muscle Invasive Bladder Cancer (HR-NMIBC) that is Persistent or Recurrent Following BCG Induction (KEYNOTE-676) Not Open Yet

Simreet

x35812

TACT Tranexamic Acid during Cystectomy Trial (TACT) Open

Simreet

x35812

 

Prostate

Study Name Description Status Contact
MAGNITUDE

A Phase 3 Randomized, Placebo-controlled, Double-blind Study of Niraparib in Combination with Abiraterone Acetate and Prednisone Versus Abiraterone Acetate and Prednisone for Treatment of Subjects with Metastatic Prostate Cancer

Open

Simreet

x35812

MYOVANT - HERO

A Multinational Phase 3 Randomized, Open-label, Parallel Group Study to Evaluate the Safety and Efficacy of Relugolix in Men with Advanced Prostate Cancer

Enrolment Closed

Simreet

x35812

MAST STUDY

A Randomized, Double-Blind, Placebo-Controlled Trial of Metformin in Reducing Progression Among Men on Expectant Management for Low Risk Prostate Cancer: The MAST (Metformin Active Surveillance Trial) Study Not Enrolling

Liz

x35214

ARN - SPARTAN

A Multicentre, Randomized, Double-blind, Phase III study of ARN-509 in men with Non-Metastatic (M0) Castration-Resistant Prostate Cancer

Enrolment Closed

Liz

x35214

MEDIVATION -PROSPER STUDY

A Mutlinational, Phase 3, Randomized, Double blind, Placebo Controlled, Efficacy and Safety Study of Enzalutamide in Patients with Non-metastatic Castrate Resistant Prostate Cancer Enrolment Closed

Liz

x35214

LATITUDE

A Randomized, Double-blind, Comparative Study of Abiraterone Acetate Plus Low-dose Prednisone Plus Androgen Deprivation Therapy (ADT) Versus ADT Alone in Newly Diagnosed Subjects With High-Risk, Metastatic Hormone-Naive Prostate Cancer (mHNPC)

Enrolment Closed

Liz

x35214

TITAN

A Phase 3 Randomized, placebo controlled, Double Blind study of JNJ-56021927 Plus Androgen Deprivation Therapy (ADT) Versus ADT in Subjects with Low- Volume Metastatic Hormone Sensitive Prostate Cancer (mHSPC)

Enrolment Closed

Liz

x35214

PIC’s Study

Advanced Prostate Imaging of Recurrent Cancer after Radiotherapy (PICs)

Enrolment Closed

Liz

x35214

PEACE III

A Randomized multicenter phase III trial comparing enzalutamide vs. a combination of Ra223 and enzalutamide in asymptomatic or mildly symptomatic castration resistant prostate cancer patients metastatic to bone.

Not Open Yet

Camilla

x35876

CRONOS II

Canadian Real Life Evaluation of the Effect of Diet and Exercise in Prostate Cancer Patients Managed with Lupron Open  

Camilla

x35876

GURC Cohort Study

A Multicentre Cohort Study of Patients with Advanced Prostate Cancer in Canada

Open

 

Simreet

x35812

 PREP Study

PSMA-PET Registry for Recurrent Prostate Cancer

Not Open Yet  

Camilla

x35876

 

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