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Innovation & Licensing Opportunities
Abstract
Renal cell carcinoma (RCC) is the most prevalent type of kidney cancer with non-clear cell RCC (nccRCC) representing 25% of RCC cases.[1] Papillary renal cell carcinoma (pRCC) is an aggressive type of RCC representing 50-64% of nccRCC cases.[2] As pRCC is a minor RCC type, it has not been extensively studied and current treatment options are limited and ineffective.[3] Effective risk stratification remains challenging in pRCC thus it is important to develop effective prognostic biomarkers and therapeutic approaches to optimize patient management.
Researchers at McMaster have developed a novel multigene signature panel that robustly predicts pRCC metastasis and fatality as well as pRCC prognosis and progression. Further, these researchers have also identified potential treatment avenues for personalized or targeted therapiesin patients with metastatic pRCC.
Creators
M.J. Chow, A. Kapoor, D. Tang
Therapeutics & Diagnostics 22-009 - Research & Innovation (mcmaster.ca)
Abstract
The 3 Wishes Project Start Up Guide was developed as a tool to help clinicians to try to improve the quality of the dying experience in ICU and to assist those who are interested in starting the project or adapting it to their own site.
Creator
D. Cook
Request Copyright License or Permission - Research & Innovation (mcmaster.ca)
3 Wishes Project – Helping to make meaningful memories at end-of-life
Abstract
TrialTree is an innovative, interactive platform designed for randomized trial design. The application provides features that include feedback on trial design, resources for trial design, tools for statistical analysis plans, and support for various trial design protocols. It is divided into modules for various aspects of trial design, including basics, design, PICO, TIDIER, SAP, full SAP, SPIRIT, and trial resources. TrialTree is already fully functional and tested.
Creator
L. Mbuagbaw
Computing & Software 22-001 - Research & Innovation (mcmaster.ca)
22-056
Abstract
Lysosomal storage diseases, such as Tay Sachs and Sandhoff disease, result from genetic mutations and can cause severe neurodegeneration in the central nervous system [1]. Although these diseases are rare, with a prevalence of approximately 1 in 100,000 [2], patients may experience severe neurological impairment and early death (infantile/juvenile forms) or delayed cognitive and speech impairments, ataxia, and lower motor neuron disease (later-onset from) [1]. Current treatments are substrate reduction therapy or enzyme replacement treatments [3]. Both treatment options have shown limited efficacy and require further research for treatment of Tay Sachs and Sandhoff disease.
Researchers at McMaster University have discovered that a repurposed FDA-approved drug is an effective treatment against Sandhoff disease in mice models. Treated mice had an increased life span and reduced muscle atrophy compared to control.
Creator
R. Austin
Therapeutics & Diagnostics 22-056 - Research & Innovation (mcmaster.ca)
23-060
Abstract
The Aggressive Incidents Scale (AIS) is an advanced and user-friendly tool designed to accurately record, monitor, and analyze aggression and violence in patients by providing a common language for healthcare professionals. The AIS facilitates improved documentation of aggression and violence, promotes clear communication based on reliable documentation, informs, and evaluates interventions, enables monitoring of escalation, and fosters risk discussion.
The AIS consists of a weekly total grid and a calendar, enabling incidents to be recorded daily, with totals provided for each week and month. This approach creates a cumulative and graphic depiction of a patient’s aggression record, making it easier for professionals to interpret the level of aggression, identify patterns, and track improvement or escalation.
The AIS can be used independently or in conjunction with the Hamilton Anatomy of Risk Management (HARM), offering versatility in various healthcare settings. The AIS language features a two-part code: the first part is a scale (1-9) indicating the severity of the incident, while the second part is a letter representing staff intervention during the incident and the type of intervention employed.
Applications
- Hospital settings, including psychiatric and forensic units.
- Homecare services for patients with aggressive tendencies.
- Research organizations studying aggression and violence in patients.
- Universities for teaching and research purposes.
- Pharmaceutical companies for clinical trials and medication efficacy studies.
Advantages
- Standardized language for consistent documentation of aggression and violence.
- Improved communication among healthcare professionals.
- Informed and targeted interventions based on reliable data.
- Efficient monitoring of escalations and patterns in patient aggression.
- Enhanced risk assessment and management.
- Integration with electronic patient records and other risk management tools.
- Applicable across various healthcare settings and disciplines.
Creators
G. Chaimowitz, M. Mamak
Abstract
The Electronic Hamilton Anatomy of Risk Management (eHARM) is a cloud-based risk assessment tool designed to streamline and enhance the process of evaluating and managing violence risk in psychiatric patients. This innovative technology combines historical data with dynamic factors to provide a comprehensive understanding of a patient’s risk of aggression, enabling clinicians to make informed decisions and develop personalized risk management strategies.
Key Features
- Comprehensive Assessment: The eHARM tool covers three stages – past, current, and future – to provide a thorough analysis of a patient’s risk of aggression, guiding clinical teams through a continuous assessment and management process.
- Predictive Capabilities: Designed to predict imminent and short-term risk, the eHARM tool applies all available information to assess and manage risk, fostering informed discussions among clinical team members.
- Patient-Level Analytics: With just a click, users can view individual trends in risk factors, aggressive incidents, clinical likelihood of violence, and escape risk, empowering clinicians to make data-driven decisions.
- Group-Level Analytics: The eHARM tool enables users to examine trends in diagnosis, risk factors, aggressive incidents, and treatment across multiple patients, providing valuable insights for program planning and resource allocation.
- Cloud-Based Platform: Accessible and secure, the eHARM tool allows for real-time collaboration among clinical teams, ensuring that assessments and risk management strategies are always up-to-date.
Applications
- Assessing and managing violence risk in inpatient and outpatient psychiatric settings.
- Guiding clinical team discussions and decision-making processes.
- Evaluating the effectiveness of treatment programs and interventions.
- Informing resource allocation and service planning.
- Conducting research on patient trajectories, risk factors, and treatment outcomes.
- The e-HARM is available in four versions: General Version, Forensic Version, Correction Version, and Youth Version
Advantages
- Comprehensive and structured approach to risk assessment and management.
- Enhances collaboration among clinical team members.
- Facilitates data-driven, evidence-based decision-making.
- Provides patient-level and group-level analytics for individualized care and program planning.
- Streamlines documentation and reporting processes through a user-friendly, cloud-based platform.
Creators
G. Chaimowitz, M. Mamak
Commercialization Successes
McMaster Molecular Medium (MMM)
3 Wishes Project
eHARM
The Hamilton Anatomy of Risk Management (HARM) is a structured clinical judgment tool that guides the assessor to formulate ...
YourCare+
YourCare+ is a free online platform helping caregivers confidently care for themselves and others. It provides helpful tools...
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